ABSTRACT
Atherosclerosis is a progressive inflammatory disorder of the arterial wall that is characterized by focal lipid rich deposits of atheroma with possible correlation with sedative hypnotics in decreasing atherogenesis. This study was performed in Al-Kadhimiya teaching hospital from February 2009 to June 2009 on sixty healthy males who were allocated to six groups. Each group was given one of the following agents: Magnesium sulfate [MgSo4], acetic acid, Meprobamate, Fluoxetine in addition to Simvastatin and water. Clinical manifestations like [arterial blood pressure, radial pulsation], lipid profiles [serum cholesterol, triglycerides, HDL, LDL and VLDL] total free radicals and platelets function tests are the parameters used in this study. All the tested agents reduce both the serum cholesterol concentration and total blood free radicals significantly; also they decrease both platelet count and adhesion test significantly. Both MgSo4 and Meprobamate lowered blood pressure and serum triglyceride concentration significantly, at the same time HDL concentration significantly changed by Fluoxetine when these parameters measured before and after treatment for 15 days. MgSo4, acetic acid, Meprobamate and Fluoxetine were found to have anti-arthrogenic activity and the possibility to be used clinically in atherosclerosis